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The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

Tested extracts and mitragynine were generally stronger inhibitors of CYP2D6 activity relative to the other isoforms 39,40

Coronary thrombosis has been associated with elevated levels of circulating l-tryptophan, which is associated with gut microbiota dysbiosis (84)

Long-term and large-scale clinical trials are essential to establish the efficacy of microbiome-based interventions in different stages of PD